Citrulline-Malate is the main compound in Stimium. I will try to explain this, on an understandable way, so let’s start with malate.

Malate

Malate, a chemical compound found in small quantities in apples, is an important part of the Krebs Cycle.

The Krebs cycle is a series of chemical reactions where we oxidise acetyl-CoA, what we got from carbohydrates, fats and protein in order to gain energy. This all happens in the mitochondria what is the so-called powerhouse, the energy generator of a cell.

Malate = Malic Acid = E296 food code.

Some scientific studies about the possible benefits of Citrulline Malate.

Citrulline

Citrulline, first isolated from watermelon, is an amino acid. It is made by the small intestine from glutamine and glutamate, then enters the blood, where the kidney extracts it, converts it to arginine and returns it to the blood.

Arginine has a lot of functions and uses from healing, to nitric oxide boosting therefor vasodilation, blood pressure control and more. It is stated on many websites quoting mostly non-reliable studies that actually ingesting citrulline is a lot more potent, than direct arginine.  If you really wanted to delve into the biology, chemistry and anatomy of this whole topic, be prepared that you’ll open up pages after pages and you’ll get into a never-ending cycle of learning. The more you research, the more you realise, first of all how much you did forget since your student years, also how much you did not know and did not understand before about research results and scientific publishing.

At the end, to calm your enthusiasm about supplements in general; if you were a superbly healthy high-end athlete, citrulline malate or any other supplements will not ever give you any real “visual” gains. It is about that extra 0.1%. However, if your diet lacked arginine or malic acid, this might provide you with an enormous boost.

“Citrulline malate

Citrulline malate (CitM) has recently become a popular supplement among bodybuilders; however, there has been little scientific research in healthy humans with this compound. CitM is hypothesised to improve performance through three mechanisms: 1) citrulline is important part of the urea cycle and may participate in ammonia clearance, 2) malate is a tricarboxylic acid cycle intermediate that may reduce lactic acid accumulation, and 3) citrulline can be converted to arginine; however, as discussed previously, arginine does not appear to have an ergogenic effect in young healthy athletes so it is unlikely CitM exerts an ergogenic effect through this mechanism”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033492/

Utilisation

I found some anecdotal uses and some bodybuilding and endurance “guru” recommandations. To really benefit from the effects of Citrulline-Malate, the minimum effective dose would be around 6grams 2 hours prior to exercise with a daily dose between 6 and 15grams. Some says we can even increase synergistically the positives, by combining CitM with other compounds like BCAA, Citrulline Ethyl-Ester HCL, l-glutamine, beta-alanine  and creatine. (This is again, just anecdotal)

The Biocodex recommended Stimium dosage is 8 x 4 (0.9g)sachets during charging phase and 3 sachets a day, during a 20day maintenance. This will come out as 3.6grams of daily consumption, from 2 pre and 2 post exercise sachets. Interestingly this is about half, than any other recommended minimal dose.

I think the taken and absorbed volume and the immediate and long-term benefits depend on so many factors. Surely, healthy stomach, intestinal and kidney functions are necessary for the proper uptake and utilisation. For this reason, I actually see the pros of taking it with glutamine, quercetine maybe even with probiotics and other gut lining protectors.

What I haven’t found, is a recommendation / fact, about taking it with a meal or not and that which macronutrient would be favorable for better absorption in that meal.

Like with all legal performance enhancing supplement studies, tell-tales and internet sites, I can clearly state, we are still searching in the dark. If it is not illegal nor harmful, many swears about it and if a quality, pharmaceutically clear and trustable product is accessible, why not try it and create more anecdotal stories ?

DAY 1 Saturday NOV 5

  • 4:00 – tired, but feeling positive
  • 4:30 – 2 Stimium sticks
  • 6:30 – Interval Training 55min = 10 x 1min hard uphill nordic walking repeats + 10 x 10 Apnea Lunges
  • 8:00 – 2 Stimium sticks
  • 14:00 – 2 Stimium sticks

DAY 2 Sunday NOV 6

  • 4:00 – Light all around soreness from yesterday’s training, still has some sickness residue, but feeling generally okay.
  • 4:30 – 2 Stimium sticks + 3grams of BCAA, High Fat Coffee and 20 Spirulina Capsules
  • 6:50 – 3hour Run = 1:30 warming up + 17minutes of climbing effort and 1hour MAF run at the end
  • 11:00 – 1 Stimium stick
  • 16:00 – 1 Stimium stick
  • 16:15 – 20minutes rowing and 10minutes of mobility

DAY 3 Monday NOV 7

  • 4:00 – Feeling great, no more soreness
  • 6:00 – 1 Stimium stick
  • 6:45 – 20min mobility 20min rowing 10min breathing
  • 8:00 – 1 Stimium stick
  • 8:10 – 60min velo
  • 14:00 – 1 Stimium stick

DAY 4 Tuesday NOV 8

  • 8:45 – Slept 11hours feeling great, no soreness
  • 10:00 – 1 Stimium stick
  • 10:10 – 30min mobility 20min rowing
  • 11:00 – 1 Stimium stick
  • 11:30 – 2hours of track workout – Athletic drills + 8 x 800 on 2:45 / Rec 2:40 + Basic strength
  • 13:00 – 1 Stimium stick

DAY 5 Wednesday NOV 9

  • 4:00 – Tired Calves
  • 5:00 – 1 Stimium stick
  • 8:00 – 40minutes mobility + rowing + 60min cycling
  • 9:30 – 1 Stimium stick
  • 19:30 – 1 Stimium stick

DAY 6 Thursday NOV 10

  • 4:00am – feeling great and slightly tight in right hips and right achilles
  • 5:45 – 1 Stimium stick
  • 6:30 – 40min mobility + rowing, 28min running + 5 x 10kb squats
  • 8:00 – 1 Stimium stick
  • 8:05 – 60min cycling
  • 14:30 – 1 Stimium stick
  • 14:35 – 38min running
  • 15:30 – 1 Stimium stick

Day 7 Friday NOV 11

  • 6:00 – Tired but motivated, after 10h of work and the additional training of yesterday. High fat coffee finally with quality, raw churned butter and a very yellow egg. No sore muscles.
  • 8:00 – 1 Stimium stick
  • 8:20 – 35min mobility + 25min rowing + 10min core
  • 10:00 – 1 Stimium stick
  • 17:00 – 1 Stimium stick
  • 17:30 – 10min mobility + 1:15 uphill nordic walking intervals + 6×10 apnea lunges
  • 19:00 – 1 Stimium stick

DAY 8 Saturday NOV 12

  • 4:00 – Big fatty coffee + Spiruline
  • 5:30 – 1 Stimium stick
  • 6:30 – 25min warming up + 1:15 MAF Run + 25min strength
  • 9:00 – 1 Stimium stick
  • 14:20 – 1 Stimium stick
  • 14:25 – 20min Run
  • 15:00 – 1 Stimium stick

After the final day, I can finally draw some conclusions. While I was training hard during this 8 day period, I never really got muscularly sore. This is very interesting and impressive, because I included more anaerobic training than usual and new style of strength sets into nearly every day’s training routines. I finished over 25 hours of training, and 36hours of work, woke up 4am 6times with one 6am and one 8am day. Averaged about 6,5hours of sleep for the 8days. I was staying mentally very active and at work I was also doing long 11hour days. Counting in the lifestyle and training stress , my recovery should have been majorly compromised, but it wasn’t .

I would not say, that it was 100% due to the Stimium. I was really focused on recuperation tools, especially because this is the last 10 days of higher intensity training block before my first “A race” of the season. I incorporated WimHof style breath-hold methods and conscious nasal diaphragmatic deep tissue breathing during training and daily life too. The foam roller, pilates and yoga, pre and post run routines were helping me in joint-mobility and muscle blood flow, therefor effecting recovery. The infrared light therapy, the regular sinus wash with the nose buddy, the cold showers and the inversion table (Traction) were also taking up a big chunk of time to ingrain training stimuli.

Still, using the Stimium was giving me surely an extra edge. If you were really into health science, you would know that belief and placebo effect is huge. I am not saying that my general great recovery was coming from the back of my mind at all, just stating that my life/sport-hack routines, self-belief and the Stimium was providing me with a “sure plus” for this 2nd high intensity macrocycle.

At this moment, I have no data on the exact ingredients. It is not published neither on the official www.Stimium.com website, nor on the producer pharmaceutical company’s www.Biocodex.fr website (13/11/2016). I sent them a letter about the excipients and to know, why of the low-dose recommendations. Still waiting for the answer. I would like to get this information out from the source itself not from a third-party, but I found this online:

“Ingredients pour 1 stick : Malate de citrulline (0,9g), eau purifiée, hydroxyde de sodium, gomme xanthane, arôme naturel d’orange sangria, hydroxyde de potassium, benzoate de sodium, sucralose.”

  • Sodium hydroxide: Buffering and ph controlling agent.
  • Xanthane Gum: Soy, corn, wheat or diary derived stabilizer, thickener or emulsifier.
  • Potassium hydroxide: Very dangerous and enormously toxic. It even decomposes live tissue.
  • Sodium Benzoate: A preservative what can create benzene by reacting with ascorbic or citric acid.
  • Sucralose: Highly questionable artificial sweetener.

While Stimium contains a very minimal amount of these substances, still all of them are linked to some sort of maladie, sickness, allergic reactions or even cancer. Regardless, that the source of those information are reliable or not, just as a clearly thinking person, why would you ever want those ingredients inside your body ?

They are ingredients and not nutrients. So while I tested the product, I understand the very ease of “tip and sqeeze” application of its gelpacks and highly enjoyed the benefits, I still cannot see using it in the future.

With very little effort, by typing Citrulline Malate into google, we can find 100% pure powder for the fraction of the price of Stimium, from BulkPowders, MyProtein or ProteinWorks. Doing an additional 5minute research would result in even more accessible 100% pure white powder. Primaforce or NutraBio looks pretty good to me for instance.

My Letter:

Bonjour,

J’aimerai bien savoir des ingredients exact dans le produit STIMIUM MC3 SVP.

Aussi j’ai une question par rapport au dosage. En regardent beaucoup d’avis anecdotique, j’ai lu partout que la minimum dose efficace, qui est utilisé par les athletes d’endurance est plutôt entre 6 et 15g par jours et des effects positifs sont visible après juste 24/36h de charge.

Vous recommandez 3.6g maxi par jours avec 8 jours de charge et 2.8g pour 20 jours de maintenance. Après la digestion, utilisation et elimination, le CdM laisse le system avec aucun trace, assez rapidement.

Par example le site Examine (bien respecté ), dit 6 ou 8gram, 1h avant l’exercise pour améliorer la performance sportif.

Merci pour votre réponse

Sportivement

LEVI

the Answer 

Bonjour,

Dans un premier temps, nous vous remercions pour l’intérêt que vous portez à Stimium et au produit MC3.

Stimium MC3 est composé de malate de citrulline, dont le dosage est de 0,9 gr.

Il a été décidé de préconiser entre 3 gr et 4 gr par jour car suite aux différentes études effectuées en interne, l’efficacité de ce principe actif est palpable à partir d’une prise de 3 gr.

Le dossier scientifique a par ailleurs été approuvé par les autorités de santé avec une prise entre 3 gr et 4 gr par jour.

 Il va sans dire que si vous le souhaitez, vous pouvez utiliser 6 à 8 sticks par jour, puisque aucun effet secondaire n’a été révélé à ce jour.

Les études que vous avez pu trouver sur internet ont été faites par des investigateurs indépendants, et sous leur propre responsabilité.

 Dans un soucis de cohérence de prise, et de mention légale, nous avons fait le choix de conseiller 3 à 4 sticks par jour, sous deux périodes : entretien et attaque, selon les échéances et entraînements de chacun.

L’objectif étant de garder une ligne directrice.

 Nos indications prévalent une prise du produit 30 minutes avant effort et 30 minutes après effort. Cette demi-heure permet une meilleure assimilation du malate de citrulline.

Nous pouvons, si cela vous intéresse, vous transmettre un dossier complet sur les différentes études effectuées.

En espérant avoir pu répondre à votre question, je reste à votre entière disposition.

Bien cordialement,

L’Equipe Stimium

So as I stated above, I might not 100% agree with all the ingredients that is used in Stimium MC3, but the company BioCodex is following responsable practice and obeying all the laws of supplement formulating.

Thanks for reading and don’t hesitate to post your queries and questions about the use and dosage of Citrulline Malate for endurance activities.